Pressure-volume relationships of tracheae in fetal newborn and adult rabbits

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Abstract

The physical properties of the trachea in fetal, newborn, and adult rabbits change with age. Tracheal dimensions and pressure-volume relationships were determined in excised tracheae at a wide developmental age range (from early gestational age to infancy and adulthodd). At intraluminal pressures of 0 to 10 cm H2O, the tracheal specific compliance was 0.089 (cm H2O)−1 for a 21 day old fetus. By adulthood, the tracheal specific compliance decreased five fold to 0.017 (cm H2O)−1; a dramatic proportion of this reduction occurred during fetal life itself, followed by a steady, progressive decline to adult age. The volume of the tracheal segment, at intraluminal pressure fo 20 cm H2O, increased by 29% (adult), 41.5% (31 day fetus) and 113% (21 day fetus). Developmental alterations in the specific airway compliance suggest significant changes in anatomical dead space would occur as a function of maturation and airway transmural pressure.

References (19)

  • J.F. Souhrada et al.

    Mechanical activities of trachea as measured in vitro and in vivo

    Respir. Physiol.

    (1976)
  • M.E. Avery et al.

    Volume-pressure relationships of lungs and thorax in fetal, newborn and adult goats

    J. Appl. Physiol.

    (1961)
  • H. Bobbaers et al.

    Dynamic viscoelastic properties of the adult canine trachae

    J. Appl. Physiol.

    (1978)
  • U. Bücher et al.

    Development of intrasegmental bronchial tree, the pattern of branching and development of cartilage at various stages of intra-auterine life

    Thorax

    (1961)
  • E.D. Burnard et al.

    Pulmonary insufficiency in prematurity

    Aust. Pediatr. J.

    (1965)
  • J.R. Croteau et al.

    Volume-pressure and length-tension measurements in human tracheal and bronchial segments

    J. Appl. Physiol.

    (1961)
  • J.R. Davidson et al.

    Effect of aging on respiratory mechanics and gas exchange in rabbits

    J. Appl. Physiol.

    (1966)
  • S. Engle

    The Prenatal Lung

  • H.L. Hahn et al.

    Effect of vagal tone on airway diameters and on lung volume in anesthetized dogs

    J. Appl. Physiol.

    (1976)
There are more references available in the full text version of this article.

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