Ureaplasma urealyticum infection of the placenta in pregnancies that ended prematurely**
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2014, Obstetrics and Gynecology Clinics of North AmericaCitation Excerpt :After treatment with erythromycin, repeat amniocentesis revealed a sterile amniotic cavity and the pregnancy continued uneventfully to term. An observational study of placental culture in successive pregnancies ending with a neonate with a birth weight of 1500 g or less revealed that presence of U urealyticum was associated with premature onset of labor as well as a decreased duration of time between rupture of membranes and delivery.30 Although not demonstrative of causality, a case-control study involving preterm labor subjects with a vaginal culture positive for U urealyticum showed that treatment with erythromycin extended the gestation and was associated with subsequent improvements in birth weight, neonatal morbidity, and shorter mean neonatal hospitalization.31
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Support for this work was provided by a grant (NS 27306) from the National Institute of Neurological Disorders and Stroke.