A sensitive method for the determination of plasma catecholamines using liquid chromatography with electrochemical detection

doi:10.1016/0024-3205(78)90665-3

Life Sciences

Volume 23, Issue 10, 11 September 1978, Pages 1049-1052

https://doi.org/10.1016/0024-3205(78)90665-3 Get rights and content

Abstract

Simple and sensitive methods for the determination of plasma catecholamines are of great interest since the level of catecholamines in plasma reflects the activity of the sympatho-adrenal system. In the present work a previously described procedure based on high pressure liquid chromatography with electrochemical detection has been adapted for assay of plasma catecholamines. This method permits simultaneous detection of noradrenaline, adrenaline and dopamine in concentrations down to 0.1 nmol/1 in less than one ml plasma.

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^☆: Supported by grants from the Swedish Medical Research Council (04X-2295, 17X-2330), Karolinska Instituet and T. och R. Söderbergs Stiftelse.

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A sensitive method for the determination of plasma catecholamines using liquid chromatography with electrochemical detection☆

Abstract

Neurosci. Lett.

Clinica Chimica Acta

J. Pharmacol. exp. Ther.

Circ. Res.