Nitrofen-induced diaphragmatic hernias in rats: An animal model☆
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2023, Current Topics in Developmental BiologyCitation Excerpt :Treatment with BMS493 of rat embryos between E8-E11 leads to CDH (Clugston et al., 2010). Similarly, treatment of pregnant dams with nitrofen or WIN18,446, teratogens that inhibit ALDH1A2 and RA synthesis (Chen et al., 2018; Noble et al., 2007), leads to CDH in mice and rats (Babiuk, Thébaud, & Greer, 2004; Kilburn, Hess, Lesser, & Oster, 1982; Kluth et al., 1990; Momma, Ando, Mori, & Ito, 1992; Rocke et al., 2021; Taleporos, Salgo, & Oster, 1978). Experiments with these pharmacological inhibitors have also provided important mechanistic insights into how defects in RA signaling lead to CDH.
Embryology and anatomy of congenital diaphragmatic hernia
2022, Seminars in Pediatric Surgery
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Presented at the 38th Annual Meeting of the Surgical Section of the American Academy of Pediatrics, Chicago, Illinois, October 21–23, 1989.
Copyright © 1990 Published by Elsevier Inc.