Elsevier

Experimental Neurology

Volume 32, Issue 3, September 1971, Pages 439-447
Experimental Neurology

Vulnerability of developing brain: VII. Permanent deficit of neurons in cerebral and cerebellar cortex following early mild undernutrition

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Abstract

Mild nutritional growth restriction during the period of the brain “growth spurt” in developing rats has resulted in a selective permanent reduction of weight and cell number in the cerebellum. Quantitative histology has also revealed permanent deficits in certain cerebral cortical neurons as well as those in the granular layer of the cerebellum.

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This work was supported by a grant from the Medical Research Council. We are also grateful to the National Fund for Research into Crippling Diseases and to the Spastics Society for their help.

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