Maturation of EEG activity during sleep in premature infants

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Abstract

  • 1.

    1. Repeated polygraphic recording of long duration were made of seventeen premature, ten full-term, and five suspected small-for-dates infants. Besides EEG, these recordings included observation of behavior and monitoring of multiple physiological parameters.

  • 2.

    2. A 3-digit code was devised for EEG patterns of infants between 28 and 40 weeks conceptional age. The first 2 digits represent the conceptional age at which a variation on the basic pattern, identified by the third digit, generally occurs. The age designations of the code system were substantiated by the distributions of EEG patterns found in records at different conceptional ages. In addition, use of the coding system differentiated small-for-dates infants from prematures.

  • 3.

    3. The observations and physiological data were used in defining 2 sleep states: quiet sleep and active sleep. Examination of the distributions of EEG patterns within each state indicated progressively distinct relationships between state and EEG pattern with maturation. Determination of conceptional age and neurological maturation was based on these relationships.

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    Based on EEG analysis, all 27- to 28-wGA premature infants demonstrate uninterrupted periods of AS than can last more than 13 min. AS are characterized by continuous or near continuous activity and the presence of REMs in non-brain damaged infants [12,15,56,57]. During the same period of development, the first spontaneous facial expressions are also observed [20,21,30,31,73].

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Supported in part by U.S. Public Health Service Grants HD 00351 and 5-TI-MH-6415. Computing assistance was obtained from the Health Sciences Computing Facility, U.C.L.A., sponsored by N.I.H. Grant FR-3.

2

Fulbright travel fellow from the Children's Clinic, University of Göttingen, Göttingen, Germany.

3

Current address: Children's Diagnostic and Study Unit, Mental Retardation Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md. 20014.

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