Glycine is required for NMDA receptor activation: electrophysiological evidence from intact rat hippocampus
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2011, Journal of EthnopharmacologyCitation Excerpt :Then a cascade of events will lead to cell death (Rothman and Olney, 1987; Choi et al., 1988; Butcher et al., 1990; Small and Buchan, 1996). Glycine in the cerebrum is an important facilitator of Glu's action through an allosteric site on the NMDA receptor (Kleckner and Dingledine, 1988; Dalkara et al., 1992; Heurteaux et al., 2006). Glycine is also increased after cerebral ischemia (Baker et al., 1991; Masaya et al., 2007).
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