The distribution of lipids in the human nervous system. III. Fatty acid composition of phosphoglycerides of human foetal and infant brain
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2022, Advances in Biological RegulationCitation Excerpt :In this sense, early studies performed by Rodriguez et al. showed that plasma membrane-bound neuraminidase may contribute to the regulation of axonal growth and regeneration of hippocampal neurons (Rodriguez et al., 2001). GD1a, GD1b, GM1, and GT1b are the major gangliosides in the adult mammalian brain (Olsen and Færgeman, 2017), including human brain (Fig. 2) (Kracun et al., 1991; O'Brien and Sampson, 1965; Svennerholm and Vanier, 1973). Regarding brain cells, SLs may found in the different CNS cell types (Fig. 3).
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2016, Advances in PediatricsCitation Excerpt :Arachidonic acid (ARA; 20:4ω6) is an omega-6 fatty acid with 20 carbons and 4 double bonds. These two fatty acids are the predominant long-chain (20 and 22 carbons) polyunsaturated fatty acids (LCPUFAs) in human brain [1,2]. Brain DHA begins to accumulate around 22 weeks’ gestation and the absolute amount per gram of brain as well as the weight percent of total fatty acids increases progressively from 22 weeks until at least 2 years of age [3–6].
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2014, Medical HypothesesCitation Excerpt :Nuts, the usual source of vitamin E, were also discouraged in favor of a low fat diet. The fetal brain requires and stores large amounts of DHA during gestation [54,55]. In the absence of adequate sources of DHA, arachidonic acid is stored instead.
Visualization of the cell-selective distribution of PUFA-containing phosphatidylcholines in mouse brain by imaging mass spectrometry
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