Elsevier

The Annals of Thoracic Surgery

Volume 54, Issue 6, December 1992, Pages 1206-1208
The Annals of Thoracic Surgery

Case report
Pneumatocele complicating hyperimmunoglobulin E syndrome (Job's syndrome)

https://doi.org/10.1016/0003-4975(92)90100-IGet rights and content

Abstract

The case of a boy with hyperimmunoglobulin E syndrome or Job's syndrome is presented to demonstrate the occurrence of pneumatoceles in this syndrome as well as their unusual natural history and failure to spontaneously resolve. Surgical resection was required for two complications in this patient, persistent bronchopleural fistula and a pulmonary abscess that destroyed one lung and required pneumonectomy. Pathologic examination of the specimens demonstrated the wall of the cysts consisted of granulation tissue with chronic active inflammation surrounded by infarcted pulmonary parenchyma with coagulative necrosis. The mechanism responsible for increased immunoglobulin E production in this syndrome is unknown, as is the manner in which elevated immunoglobulin E levels impair normal immune function.

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