Maternal plasma level of endothelin is increased in preeclampsia
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Cited by (199)
Vascular Endothelial Cell Dysfunction in Preeclampsia
2021, Chesley’s Hypertensive Disorders in PregnancyPlacentation and Placental Function in Normal and Preeclamptic Pregnancies
2021, Chesley’s Hypertensive Disorders in PregnancyIssues in the interpretation of serum endothelin levels in preeclampsia
2019, Medical HypothesesCitation Excerpt :Not long after the discovery of endothelin [1,2], several studies demonstrated that serum levels of this substance were significantly elevated in women who had preeclampsia [3–6].
A review of the associations between obstructive sleep apnea and hypertensive disorders of pregnancy and possible mechanisms of disease
2018, Sleep Medicine ReviewsCitation Excerpt :Blood pressure was reduced by administering PlGF to animals in an experimental model of preeclampsia [97]. SFlt-1 and sEng levels are both associated with increased levels of endothelin-1, another potent vasoconstrictor that is elevated in preeclampsia [98]. Antagonism of its downstream receptor (endothelin Type A receptor) has been studied as a means of mitigating the hypertensive effects of these proteins in animal models, and as a potential future therapeutic target in humans [56,99].
Mechanisms and Clinical Significance of Endothelial Dysfunction in High-Risk Pregnancies
2018, Canadian Journal of CardiologyCitation Excerpt :In addition, serum and urine levels of NO and the stable NO metabolites nitrite and nitrate were significantly reduced in pregnant women with preeclampsia, compared with normotensive pregnant women, although other trials have reported conflicting results.27-30 It has been widely reported that plasma levels of endothelin-1 are significantly elevated in women with preeclampsia, compared with normotensive pregnant women.30,33-35 Women who developed preeclampsia also exhibit increased circulating levels of NTproCNP from 24 weeks' gestation to delivery compared with normotensive pregnant women, potentially representing an adaptive response to an increased vasoconstricted state or reduced clearance, because of renal dysfunction.31,32
The role of aspirin, heparin, and other interventions in the prevention and treatment of fetal growth restriction
2018, American Journal of Obstetrics and GynecologyCitation Excerpt :The release of sFlt-1 and soluble endoglin6,7 into the maternal circulation causes endothelial dysfunction, a feature of the placenta-mediated complications of pregnancy and in particular preeclampsia, and an imbalance in vasoactive factors such as endothelin,13 nitric oxide,14 and prostacyclin,15 resulting in reduced vasodilatation and increased vasoconstriction.