Amniotic fluid erythropoietin predicts fetal distress in Rh-immunized pregnancies
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Cited by (55)
Early Biomarkers of Hypoxia and Inflammation and Two-Year Neurodevelopmental Outcomes in the Preterm Erythropoietin Neuroprotection (PENUT) Trial
2021, EBioMedicineCitation Excerpt :These are most likely due to accidental measurement of trough levels on day 7 and peak levels on day 9 and are not expected to alter the results of our analysis. Elevated fetal endogenous Epo levels have been associated with a variety of high-risk fetal conditions, including maternal diabetes, fetal distress in Rh-immunised pregnancies, and intrauterine hypoxia [28-32]. Measurements of Epo in amniotic fluid have also been associated with biomarkers of oxidative and nitrosative stress [33].
Umbilical cord erythropoietin concentrations and metabolic status in newborns with intrapatum fetal distress
2016, Clinica e Investigacion en Ginecologia y ObstetriciaStillbirth in diabetic pregnancies
2011, Best Practice and Research: Clinical Obstetrics and GynaecologyCitation Excerpt :The occurrence of stillbirths and foetuses with signs of hypoxia is increased in pregnancies complicated by pre-eclampsia, diabetes and foetuses large or small for gestational age. These are also conditions in which foetal acidosis and increased plasma and amniotic fluid values of erythropoietin (EPO) have been observed.12–16 Hypoxia is the major stimulus of EPO synthesis in both the foetus and the adult.
Obstetric problems in diabetic pregnancy - The role of fetal hypoxia
2010, Best Practice and Research: Clinical Endocrinology and MetabolismCitation Excerpt :Abnormal uterine artery Doppler flow has been observed in women with diabetic vascular changes,66 but this does not seem to correlate with fetal hypoxaemia or acidaemia.67 Exponential increase in amniotic fluid EPO levels in high-risk pregnancies has been associated with fetal hypoxia68,69 including type 1 diabetic pregnancies.37 In the study by Teramo et al.38 high amniotic fluid EPO levels were observed before labour in 21 out of 156 (13.5%) consecutive type 1 diabetic pregnancies with a caesarean section delivery.
Amniotic fluid S100B protein and erythropoietin in pregnancies at risk for fetal hypoxia
2009, European Journal of Obstetrics and Gynecology and Reproductive BiologyCitation Excerpt :Because erythropoietin does not cross the placenta, raised amniotic fluid erythropoietin levels indicate hypoxia in fetal tissues [12]. Abnormally high amniotic fluid erythropoietin concentration is frequently found in pregnancies complicated by diabetes, pre-eclampsia, intrauterine growth restriction, erythroblastosis, and fetal death after a chronic hypoxic event, whereas it remains unaltered in situations with short-lasting hypoxia, such as umbilical cord complications and placental abruption [6,13–16]. Thus, chronic and acute fetal hypoxia can be differentiated by measurement of amniotic fluid erythropoietin concentration.
Sources of amniotic fluid erythropoietin during normoxia and hypoxia in fetal sheep
2006, American Journal of Obstetrics and GynecologyCitation Excerpt :Another objective was to explore changes in erythropoietin concentration in AF and other fetal fluids during various forms of fetal hypoxia. Our finding that ovine AF erythropoietin concentration undergoes a small increase during severe but not during mild or moderate fetal hypoxia is surprising in view of the elevated AF erythropoietin concentrations reported in hypoxic human fetuses, which has led to the suggestion that an elevated AF erythropoietin concentration could be used as an index of chronic fetal hypoxia in humans.3-6 Clearly, our data in sheep, from studies that used different experimental approaches and invoked different underlying mechanisms to produce hypoxia, do not support this suggestion because 10-fold increases in fetal plasma erythropoietin concentration in response to hypoxia over hours to days were not associated with markedly elevated AF concentrations, as was observed for human fetuses that were studied under high-risk conditions that were associated with fetal hypoxia.
Supported in part by grants from the March of Dimes Birth Defect Foundation, the National Institute of Child Health and Human Development (HD-11343), the National Heart, Lung and Blood Institute (NHLBI-22469), the Rhode Island Hospital Research Fund, and the Nordisk Insulin Research Fund.