Amniotic band syndrome: Reevaluation of its pathogenesis

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Abstract

Amniotic band syndrome is a poorly defined entity characterized by protean fetal malformations and disruptions. The pathogenic theory widely accepted in the obstetric literature is that the formation of fibrous amniotic bands is the initiating event in the disorder and is responsible for subsequently pathologic conditions. A critical review of the recent clinical and experimental literature appears to contradict this hypothesis. Evidence suggests that amniotic band syndrome results from a multifactorial process in which vascular compromise, specifically hemorrhage, is the principal pathogenic stimulus and that the fibrous bands are a late, reparative event of little or no pathogenic significance. (AM J OBSTET GYNrECOL 1989;160:1030-3.)

Key words

Amniotic band syndrome
etiology
pathogenesis

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