Acute modulation of the hypothalamic-pituitary axis by intravenous testosterone in normal women☆,☆☆
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Cited by (59)
The impact of genetic steroid disorders on human fertility
2023, Genetic Steroid Disorders: Second EditionPathological pulses in PCOS
2019, Molecular and Cellular EndocrinologyCitation Excerpt :Given that androgens antagonize progesterone negative feedback (Blank et al., 2009; Pielecka et al., 2006) the presence of hyperandrogenism at this pubertal stage would result in high frequency LH pulses in both the day and night, promoting even greater androgen production and further promotion of impaired negative feedback (Kim et al., 2018). Acute androgen administration to normal ovulatory women does not increase LH, in fact, it suppresses serum LH (Serafini et al., 1986). However, long term administration of androgen receptor antagonists to PCOS patients can ameliorate impaired negative feedback, indicating that chronic hyperandrogenism contributes to the impaired steroid hormone sensitivity of the GnRH neuronal network (Eagleson et al., 2000).
Polycystic Ovary Syndrome and Hyperandrogenic States
2019, Yen & Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management: Eighth EditionThe impact of genetic steroid disorders on human fertility
2017, Journal of Steroid Biochemistry and Molecular BiologyCitation Excerpt :Treatment with androgen-blocking agents evokes a similar restoration of LH pulse frequency in hyper-androgenic individuals [10]. While such data is compelling, experiments involving infusion of androgens to healthy subjects as well as those with PCOS fails to alter basal LH secretion, and indeed can have the opposite effect, reducing serum LH levels [11,12]. Indeed, the role exerted by androgens on central gonadotropin pulsatility is complex and deserving of further study.
Fertility in patients with congenital adrenal hyperplasia
2014, Fertility and SterilityCitation Excerpt :Such studies suggest that androgens may impede normal central feedback mechanisms. Not all evidence, however, supports this mechanism; infusion of androgens to women with PCOS as well as to normal controls did not alter basal LH secretion, and in fact high-dose exogenous androgens administered to normal women acutely reduced serum LH levels (23, 24). The exact effects of elevated androgens at the level of the hypothalamus and pituitary thus need to be further elucidated.
The Impact of Genetic Steroid Disorders on Human Fertility
2014, Genetic Steroid Disorders
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This work was supported in part by National Institutes of Health Grant HD 17519 and National Institutes of Health, General Clinical Research Center Grant RR-43.
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Presented in part at the Thirty-second Annual Meeting of the Society for Gynecologic Investigation, Phoenix, Arizona, March 20–23, 1985.