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Pulmonary hypertension, heart failure and neutropenia due to diazoxide therapy

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Abstract

Primary persistent hyperinsulinaemic hypoglycaemia is characterised by clinical symptoms that occur when blood glucose levels drop below the normal range. Diazoxide treatment remains the mainstay of medical therapy. Tolerance of diazoxide is usually excellent, but several side effects of this drug have been described. We present a 4-month-old girl who developed pulmonary hypertension, heart failure and neutropenia during diazoxide therapy. Diazoxide toxicity was suspected and the drug was withdrawn on day 13. During the next 3 days, respiratory and haemodynamic status dramatically improved and she was weaned from mechanical ventilation. Control white blood cell count was 8800 cells/mm3 and a new echocardiography showed modreduction of pulmonary artificial pressure to 20 mmHg and resolution of atrial and ventricular enlargement. Paediatric physicians should be in mind of pulmonary hypertension, heart failure and neutropenia developing during diazoxide therapy.

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Authors and Affiliations

  1. Department of Paediatric Intensive Care Unit, Çukurova University, Faculty of Medicine, 01330, Adana, Turkey

    Dincer Yildizdas

  2. Department of Paediatric Cardiology, Çukurova University, Faculty of Medicine, Adana, Turkey

    Sevcan Erdem & Osman Küçükosmanoǧlu

  3. Department of Paediatrics, Çukurova University, Faculty of Medicine, Adana, Turkey

    Mustafa Yilmaz

  4. Department of Paediatric Endocrinology and Metabolism, Çukurova University, Faculty of Medicine, Adana, Turkey

    Bilgin Yüksel

Authors
  1. Dincer Yildizdas
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  2. Sevcan Erdem
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  3. Osman Küçükosmanoǧlu
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  4. Mustafa Yilmaz
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  5. Bilgin Yüksel
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Correspondence to Dincer Yildizdas.

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Yildizdas, D., Erdem, S., Küçükosmanoǧlu, O. et al. Pulmonary hypertension, heart failure and neutropenia due to diazoxide therapy. Adv Therapy 25, 515–519 (2008). https://doi.org/10.1007/s12325-008-0049-3

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  • DOI: https://doi.org/10.1007/s12325-008-0049-3

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