Abstract.
We report the use of continuous arteriovenous hemodiafiltration (CAVHD) in a neonate with severe hyperammonemia due to a urea cycle disorder. We compared the ammonia clearance (C NH3) for peritoneal dialysis (PD) and CAVHD. C NH3 for CAVHD was 7.45 ml/min per m2 at a dialysate flow of 300 ml/h and was 10.55 ml/min per m2 at a dialysate flow rate of 600 ml/h. The mean PD clearance was 2.15 ml/min per m2. Our data suggest that CAVHD is superior to PD for the removal of plasma ammonia. We conclude that CAVHD should be considered a reasonable alternative in the treatment of neonatal hyperammonemia in urea cycle disorders when medical treatment fails.
Article PDF
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received September 2, 1997; received in revised form Feburary 26, 1998; accepted March 2, 1998
Rights and permissions
About this article
Cite this article
Wong, K., Wong, S., Lam, S. et al. Ammonia clearance by peritoneal dialysis and continuous arteriovenous hemodiafiltration. Pediatr Nephrol 12, 589–591 (1998). https://doi.org/10.1007/s004670050511
Issue Date:
DOI: https://doi.org/10.1007/s004670050511