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Elimination half-life of vitamin K1 in neonates is longer than is generally assumed: implications for the prophylaxis of haemorrhaghic disease of the newborn

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References

  1. Von Kries R, Hanawa Y (1993) Neonatal Vitamin K Prophylaxis, Thrombosis and Haemostasis 69:293–295

    Google Scholar 

  2. McNinch AW, Tripp JH (1991) Haemorrhagic disease of the newborn in the British Isles: Two years prospective study. Br Med J 303:1105–1108

    Google Scholar 

  3. Cornelissen EAM, Kollée LAA, De Abreu RA, van Baal JM, Motohara K, Verbruggen B and Monnens LAH (1992) Effects of oral and intramuscular vitamin K prophylaxis on vitamin K1, PIVKA-II and clotting factors in breast fed infants. Arch Dis Child 67:1250–1254

    Google Scholar 

  4. Sutor AH, Dagres N, Niederhoff H (1993) Parenteral verabreichtes Vitamin K und erhöhtes Krebsrisiko? Hautnah Paed 3:164–180

    Google Scholar 

  5. Schubiger G, Tönz O, Grüter J, Shearer MJ (1993) Vitamin K1 concentration in breast-fed neonates after oral or intramuscular administration of a single dose of a new mixed micellar preparation of phylloquinone. J Pediatr Gastroenterol Nutr 16:435–439

    Google Scholar 

  6. Øie S, Trenk D, Guentert TW, Mosberg H, Jähnchen E (1988) Disposition of vitamin K1 after intravenous and oral administration to subjects on phenprocoumon therapy. Int J Pharm 48:223–230

    Google Scholar 

  7. McNinch AW, Upton C, Samuels M, Shearer MJ, McCarthy P, Tripp JH, Orme RL (1985) Plasma concentration after oral or intramuscular vitamin K1 in neonates. Arch Dis Child 60:814–818

    Google Scholar 

  8. Amédée-Manesme O, Lambert WE, Alagille D, Leenheer AP (1992) Pharmacokinetics and safety of a new solution of vitamin K1 in children with cholestasis. J Pediatr Gastroenterol Nutr 14:160–165

    Google Scholar 

  9. Widdershoven J, Lambert W, Motohara K, Monnens L, De Leenheer A, Matsuda I, Endo F (1988) Plasma concentrations of vitamin K1 and PIVKA II in bottle-fed and breast-fed infants with and without vitamin K prophylaxis at birth. Eur J Pediatr 148:139–142

    Google Scholar 

  10. Motohara K, Matsukura M, Matsuda I, Iribe K, Ikeda T, Kond Y, Yonekubu A, Yamamoto Y, Tsuchiya Y (1984) Severe vitamin K deficiency in breast-fed infants. J Paediatr 105:943–945

    Google Scholar 

  11. Joubert PH and Stoeckel K (1994) Oral vitamin K in breast-fed infants to prevent late haemorrhagic disease of the new-born. Lancet 344:483–484

    Google Scholar 

  12. McNinch AW and Tripp JH (1991) Haemorrhagic disease of the newborn in the British Isles: two year prospective study. Br Med J 303:1105–1109

    Google Scholar 

  13. Von Kries R, Göbel U (1994) Oral vitamin K prophylaxis and late haemorrhagic disease of the newborn. Lancet 343:352

    Google Scholar 

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Stoeckel, K., Joubert, P.H. & Grüter, J. Elimination half-life of vitamin K1 in neonates is longer than is generally assumed: implications for the prophylaxis of haemorrhaghic disease of the newborn. Eur J Clin Pharmacol 49, 421–423 (1996). https://doi.org/10.1007/BF00203790

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  • DOI: https://doi.org/10.1007/BF00203790

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