Abstract
A female with congenital adrenal hyperplasia (21-hydroxylase deficiency) received prenatal dexamethasone treatment. Suppression of the fetal adrenal was initially inadequate but adequate in later pregnancy. The baby showed masculinisation without clitoral enlargement and a narrow urogenital sinus with resulting hydrometrocolpos. It is possible that dexamethasone treatment which is initially inadequate increases the risk of this latter complication.
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Abbreviations
- CAH:
-
congenital adrenal hyperplasia
References
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Couper, J.J., Hutson, J.M. & Warne, G.L. Hydrometrocolpos following prenatal dexamethasone treatment for congenital adrenal hyperplasia (21-hydroxylase deficiency). Eur J Pediatr 152, 9–11 (1993). https://doi.org/10.1007/BF02072507
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DOI: https://doi.org/10.1007/BF02072507