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Somatomedin-binding proteins: What role do they play in the growth process?

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Abstract

The insulin-like growth factors (IGF-I and IGF-II) circulate bound to specific proteins. Two classes of binding proteins have been relatively well characterized differing in size, immunological activity, and physiological function. This review summarizes the more recent data on IGF-binding proteins, focusing on their possible clinical implications.

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Abbreviations

GH:

growth hormone

IGF-BP:

insulin-like growth factor binding protein

IGF (I and II):

insulin-like growth factor (I and II)

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Authors and Affiliations

  1. Department of Paediatrics, “Tor Vergata” University Medical School, II University of Rome, Dip. San. Biol. Cell., Via O. Raimondo, I-00173, Roma, Italy

    S. Cianfarani

  2. Department of Chemical Endocrinology, St. Bartholomew's Hospital, London, UK

    J. M. P. Holly

Authors
  1. S. Cianfarani
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  2. J. M. P. Holly
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Cianfarani, S., Holly, J.M.P. Somatomedin-binding proteins: What role do they play in the growth process?. Eur J Pediatr 149, 76–79 (1989). https://doi.org/10.1007/BF01995850

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  • DOI: https://doi.org/10.1007/BF01995850

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