Abstract
Clinical parameters, available on day 4, were collected for 204 ventilated neonates <32 weeks gestation. Logistic regression was used to identify factors significantly and independently associated with chronic neonatal lung disease (CNLD) at 36 weeks postconception, which developed in 29% of neonates. At 36 weeks birth weight, peak inspiratory ventilator pressure and requirement for assisted ventilation on day 4 were such factors. The logistic regression equation for this association was applied to each infant resulting in a value between 0 and 1. By knowing which neonates developed CNLD, the discriminatory ability of this value was assessed. A receiver-operator characteristic curve for this value had an area under the curve of 0.97 (SE 0.03) in an unrelated population. A logistic equation value >0.4 had a sensitivity of 90% and a specificity of 88% in predicting CNLD at 36 weeks.
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Abbreviations
- CNLD :
-
chronic neonatal lung disease
- LV :
-
logistic value
- ROC :
-
receiver-operator characteristic
- SE :
-
standard error
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Ryan, S.W., Nycyk, J. & Shaw, B.N.J. Prediction of chronic neonatal lung disease on day 4 of life. Eur J Pediatr 155, 668–671 (1996). https://doi.org/10.1007/BF01957150
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DOI: https://doi.org/10.1007/BF01957150