Summary
The aim of the study was to use a novel combination of two methods for the simultaneous evaluation of two effects of oral cisapride in 10 diabetic patients with autonomic neuropathy; gastric emptying time was measured by following radio-opaque markers and orocaecal transit time by the sulphasalazine-sulphapridine method. The study was of double-blind, randomized, placebo-controlled, cross-over design.
It was possible to evaluate the effect of a prokinetic drug on gastric emptying and orocaecal transit times using these two noninvasive techniques at the same time. Cisapride significantly reduced both the gastric emptying (1.2 h versus 2.1 h) and orocaecal tansit (5.9 h versus 7.7 h) times.
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Bergmann, J.F., Chassany, O., Guillausseau, P.J. et al. Simultaneous noninvasive evaluation of gastric emptying and orocaecal transit times. Eur J Clin Pharmacol 43, 121–124 (1992). https://doi.org/10.1007/BF01740656
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DOI: https://doi.org/10.1007/BF01740656