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Postnatal retinal development as measured by the electroretinogram in premature infants

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Abstract

Light-adapted and dark-adapted electroretinograms were obtained in 27 premature infants who were screened for retinopathy of prematurity shortly after birth. Thirteen showed no retinopathy and 13 had mild to moderate retinopathy, which ranged from stage I, zone III (International Classification) to stage III, zone II. Measurements were made during the first 16 months of life. The configuration of the waveforms under both photopic and scotopic conditions changed during this period showing increased amplitudes of both the a- and the b-waves. A scotopic intensity series was performed and the b-wave amplitudes and implicit times were measured. The b-wave amplitude data were averaged for three adult control subjects, for infants without retinopathy of prematurity measured at 3–4 and at 6–7 months and for infants with retinopathy of prematurity measured at 3–4 and at 6–7 months. The Naka-Rushton function was fitted to the average data. The Rmax increased from 3 to 6 months and from 6 months to adulthood, and the Isat values decreased over this age range. The b-wave implicit times were within normal range in the 6-month data. There was no difference in Rmax or Isat for infants with and without ROP.

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References

  1. Hendrickson AE, Youdelis C. The morphological development of the human fovea. Ophthalmologica 1984; 91: 603–12.

    Google Scholar 

  2. Youdelis C, Hendrickson A. A qualitative and quantitative analysis of the human fovea during development. Vision Res 1986; 26: 847–55.

    Google Scholar 

  3. Wilson HR, Mets MB, Nagy SE, et al. Albino spatial vision as an instance of arrested visual development. Vision Res 1988; 28: 979–90.

    Google Scholar 

  4. Gwiazda J, Brill S, Monindra I, et al. Preferential looking acuity in infants from two to fifty-eight weeks of age. Am J Optom Physiol Opt 1980; 57: 428–32.

    Google Scholar 

  5. Teller DY, Movshon JA. Visual development. Vision Res 1986; 26: 1438–1506.

    Google Scholar 

  6. De Rouck A. ERG in childhood. Bull Soc Belge Ophthalmol 1982; 202: 97–113.

    Google Scholar 

  7. Zetterstrom B. The clinical electroretinogram. IV. The electroretinogram in children during the first year of life. Acta Ophthalmol 1951; 29: 295–304.

    Google Scholar 

  8. Zetterstrom B. Flicker electroretinography in newborn infants. Acta Ophthalmol 1955; 33: 157–66.

    Google Scholar 

  9. Heck J, Zetterstrom B. Analyse des photopischen Flimmerelktroretinograms bei neugeborenen. Ophthalmologica 1958; 135: 205–10.

    Google Scholar 

  10. Zetterstrom B. The electroretinogram of the newborn infant. Int Ophthalmol Clin 1969; 9: 1039–49.

    Google Scholar 

  11. Horsten GPM, Winkleman JE. Development of the ERG in relation to histological differentiation of the retina in man and animals. Arch Ophthalrnol 1960; 63: 232–42.

    Google Scholar 

  12. Horsten GPM, Winkleman JE. Electrical activity of the retina in relation to histological differentiation in infants born prematurely and at full term. Vision Res 1962; 2: 269–276.

    Google Scholar 

  13. Shipley T, Anton MT. The human electroretinogram in the first day of life. J Pediatr 1964; 65: 7337–9.

    Google Scholar 

  14. Lodge A, Armington JC, Barnet AB, Shanks BL, Newcomb CN. Newborn infants' electroretinograms and evoked electroencephalographic responses to orange and white light. Child Dev 1969; 40: 267–93.

    Google Scholar 

  15. Fulton AB, Hansen RM. Electroretinography. Application to clinical studies of infants. J Pediatr Ophthalmol Strabismus 1985; 22: 251–5.

    Google Scholar 

  16. Fogarty TP, Reuben RN. Light-evoked cortical and retinal responses in premature infants. Arch Ophthalmol 1969; 81: 454–9.

    Google Scholar 

  17. Birch EE, Birch DG, Petrig B, et al. Retinal and cortical function of very low birth weight infants at 36 and 57 weeks post-conception. Clin Vis Sci 1990; 5: 363–73.

    Google Scholar 

  18. Committee for the Classification of Retinopathy of Prematurity. An international classification of retinopathy of prematurity. Arch Ophthalmol 1984; 102: 1130.

    Google Scholar 

  19. Wali N, Lequire LE. Fundus pigmentation and the dark-adapted electroretinogram. Doc Ophthalmol 1992; 80: 1–12.

    Google Scholar 

  20. Sawusch M, Pokorny J, Smith VC. Clinical electroretinography for short wavelength sensitive cones. Invest Ophthalmol Vis Sci 1987; 28: 966–74.

    Google Scholar 

  21. Peachey NS, Alexander KR, Fishman GA. The luminance-response function of the dark-adapted human electroretinogram. Vision Res 1989; 29: 263–70.

    Google Scholar 

  22. Hood DC, Birch DG. A computational model of the amplitude and implicit time of the b-wave of the human rod ERG. Vis Neurosci 1992; 8: 107–26.

    Google Scholar 

  23. Breton ME, Montzka DP. Empiric limits of rod photocurrent component underlying a-wave response in the electroretinogram. Doc Ophthalmol 1992; 79: 337–61.

    Google Scholar 

  24. Fulton AB, Hansen RM. Background adaptation in human infants. Analysis of b-wave responses. Doc Ophthalmol Proc Ser 1982; 31: 191–7.

    Google Scholar 

  25. Hood DC, Birch DG, Birch EE. Use of models to improve hypothesis delineation. A study of infant electroretinography.In: Simons K, ed. Early visual development. Normal and abnormal. New York: Oxford University Press, 1993: 517–35.

    Google Scholar 

  26. Mactier H, Dexter JD, Hewett JE, Latham CB, Woodruff CW. The electroretinogram in preterm infants. J Pediatr 1988; 113: 607–12.

    Google Scholar 

  27. Hood DC, Birch DG. The a-wave of the human ERG and rod receptor function. Invest Ophthalmol Vis Sci 1990; 31: 2070–81.

    Google Scholar 

  28. Hood DC, Birch DG. A quantitative measure of the electrical activity of human rod photoreceptors using electroretinography. Vis Neurosci 1990; 5: 379–87.

    Google Scholar 

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Mets, M.B., Smith, V.C., Pokorny, J. et al. Postnatal retinal development as measured by the electroretinogram in premature infants. Doc Ophthalmol 90, 111–127 (1995). https://doi.org/10.1007/BF01203332

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