Summary
Three infants with neonatal convulsions were given lidocaine infusions for three days, three weeks and three months, respectively, and the plasma concentrations of lidocaine and its metabolites were analyzed by HPLC.
After a prolonged infusion there was considerable accumulation of the metabolites.
This may account for the difficulty of stopping the infusion without relapse of the seizures.
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Wallin, A., Nergårdh, A. & Hynning, P.Å. Lidocaine treatment of neonatal convulsions, a therapeutic dilemma. Eur J Clin Pharmacol 36, 583–586 (1989). https://doi.org/10.1007/BF00637740
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DOI: https://doi.org/10.1007/BF00637740