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Dosage effect of SOD-A gene in 21-trisomic cells

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Summary

SOD-A activity was measured by the polarographic method of catalytic currents in 30 subjects 10–24 years of age with a karyotype 47, +21, and 30 age matched normal subjects. The ratio of the average amount of SOD-A in 21-trisomic cells to the average amount in normal cells is 1.4495. Statistical analysis confirms that this ratio does not differ significantly from the ratio 1.5 expected in the case of a simple gene dosage effect.

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Authors and Affiliations

  1. Institute of Human Genetics, Catholic University School of Medicine, Rome, Italy

    N. Crosti & A. Serra

  2. Institute of Physical Chemistry, University of Venice, Venice, Italy

    A. Rigo & P. Viglino

Authors
  1. N. Crosti
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  2. A. Serra
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  3. A. Rigo
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  4. P. Viglino
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Additional information

This work was supported by a grant of the Ministry of Health, No. 500.6/1143.

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Crosti, N., Serra, A., Rigo, A. et al. Dosage effect of SOD-A gene in 21-trisomic cells. Hum Genet 31, 197–202 (1976). https://doi.org/10.1007/BF00296146

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  • DOI: https://doi.org/10.1007/BF00296146

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