Skip to main content

The Central Role of PAF in Necrotizing Enterocolitis Development

  • Chapter

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 407))

Abstract

Platelet-activating factor (PAF) is a potent lipid mediator which has been implicated in a number of disease processes including thrombosis, sepsis, asthma, inflammatory bowel disease, etc.1 A role for PAF has also been demonstrated in a number of physiological processes, including reproductive biology and fetal development.2

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. F. Snyder, Platelet-activating factor and related acetylated lipids as potent biologically active cellular mediators, Am. J. Physiol. 259:C697 (1990).

    PubMed  CAS  Google Scholar 

  2. K. Toyoshima, H. Narahara, M. Furukawa, R.A. Frenkel, and J.M. Johnston, Platelet-activating factor. Role in fetal lung development and relationship to normal and premature labor. Clin. In Perinatol. 22:263 (1995).

    CAS  Google Scholar 

  3. F. Gonzalez-Crussi, and W. Hsueh, Experimental model of ischemic bowel necrosis. The role of plateletactivating factor and endotoxin, Am. J. Pathol. 112:127 (1983).

    PubMed  CAS  Google Scholar 

  4. M. Furukawa, E.L. Lee, and J.M. Johnston, Platelet-activating factor-induced ischemic bowel necrosis: The effect of platelet-activating factor acetylhydrolase, Pediatr. Res. 34:347 (1993).

    Article  Google Scholar 

  5. W.E.I. Hsueh, F. Gonzalez-Crussi, J.L. Arroyave, R.C. Anderson, M.L. Lee, and W.J. Houlihan, Platelet-activating factor-induced ischemic bowel necrosis: The effect of PAF antagonists, Eur. J. Pharmacol. 123:79 (1986).

    Article  PubMed  CAS  Google Scholar 

  6. K. Yasuda, and J.M. Johnston, The hormonal regulation of platelet-activating factor-acetylhydrolase in the rat, Endocrinology 130:708 (1992).

    Article  PubMed  CAS  Google Scholar 

  7. A. Lucas, T.J. Cole, Breast milk and neonatal necrotizing enterocolitis, Lancet 336:1519 (1990).

    Article  PubMed  CAS  Google Scholar 

  8. M. Furukawa, H. Narahara, K. Yasuda, and J.M. Johnston, Presence of platelet-activating factor acetylhydrolase in milk, J. Lipid Res. 34:1603 (1993).

    PubMed  CAS  Google Scholar 

  9. M.S. Caplan, and W. MacKendrick, Inflammatory mediators and intestinal injury, Clin. In Perinatol. 21:235 (1994).

    CAS  Google Scholar 

  10. H. Narahara, and J.M. Johnston, Effects of endotoxins and cytokines on the secretion of platelet-activating factor-acetylhydrolase by human decidual macrophages, Am J. Obstet. Gynecol. 169:531 (1993).

    Article  PubMed  CAS  Google Scholar 

  11. K. Yasuda, H. Eguchi, H. Narahara, and J.M. Johnston, Platelet-activating factor: Its regulation in parturition, in: Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury, S. Nigam, K.V. Honn, L.J. Marnett, J.L. Waiden, eds., Kluwer Academic Publishers, Norwell, MA, p. 727 (1993).

    Chapter  Google Scholar 

  12. L.W. Tjoelker, C. Wilder, C. Eberhardt, D.M. Stafforini, G. Dietsch, B. Schimpf, S. Hooper, H.L. Trong, L.S. Cousens, G.A. Zimmerman, Y. Yamada, T.M. Mclntyre, S.M. Prescott, and P.W. Gray, Anti-inflammatory properties of a platelet-activating factor-acetylhydrolase, Nature 374:549 (1995).

    Article  PubMed  CAS  Google Scholar 

  13. Y. Ihara, R.A. Frenkel, and J.M. Johnston, Hormonal regulation of PAF-acetylhydrolase activity in rat tissues, Arch. Biochem. Biophys. 304:503 (1993).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer Science+Business Media New York

About this chapter

Cite this chapter

Muguruma, K., Gray, P.W., Tjoelker, L.W., Johnston, J.M. (1997). The Central Role of PAF in Necrotizing Enterocolitis Development. In: Honn, K.V., Marnett, L.J., Nigam, S., Jones, R.L., Wong, P.YK. (eds) Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3. Advances in Experimental Medicine and Biology, vol 407. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1813-0_56

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-1813-0_56

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1815-4

  • Online ISBN: 978-1-4899-1813-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics