Table 3

Brain injury on neonatal MRI

Area of injuryScoreErythropoietin (n=20)Placebo (n=13)
Basal ganglia and thalami injury (BGT)
Normal (0)8 (40.0%)6 (46.2%)
Mild (1)7 (35.0%)2 (15.4%)
Moderate (2)1 (5%)5 (38.5%)
Severe (3)4 (20.0%)0
Posterior limb of internal capsule (PLIC)
Normal (0)9 (45%)4 (30.8%)
Equivocal (1)5 (25.0%)3 (23.1%)
Abnormal (2)6 (30.0%)6 (46.2%)
White matter (WM)
Normal (0)4 (20.0%)1 (7.7%)
Mild (1)2 (10%)1 (7.7%)
Moderate (2)10 (50%)10 (76.9%)
Severe (3)4 (20.0%)1 (7.7%)
Cortex
Normal (0)9 (45.0%)9 (69.2%)
Mild (1)5 (25.0%)2 (15.4%)
Moderate (2)1 (5%)0
Severe (3)5 (25%)2 (15.4%)
Any area
BGT >0 or PLIC >0 or WM >1 or cortex >118 (90%)12 (92.3%)
Cerebral bleeds2 (10%)0
Sinus venous thrombosis2 (10%)0
  • No significant difference was noted between brain injury scores in erythropoietin and placebo groups.