Table 2

Penicillin G plasma concentrations in relation to the time interval between administration and delivery (mothers) and birth (cord blood infants)*†

Mothers
Time interval from administration of antibiotics to deliveryPenicillin G (mg/L)
N=44
 <1 hour0.17 (0.00–0.53) (n=7)
 1–2 hours0.93 (0.00–1.07) (n=11)
 2–3 hours0.00 (0.00–0.68) (n=14)
 3–4 hours0.17 (0.00–0.71) (n=6)
 >4 hours0.00 (0.00–0.49) (n=6)
Infants
Time interval from administration of antibiotics to birthPenicillin G (mg/L)
N=44
 <1 hour5.54 (3.42–8.27) (n=7)
 1–2 hours2.97 (0.67–5.16) (n=11)
 2–3 hours1.28 (0.68–3.28) (n=14)
 3–4 hours0.46 (0.19–1.01) (n=6)
 >4 hours0.66 (0.44–1.43) (n=6)
  • *Results are presented as median (IQR).

  • †The recommended interval of 4 hours between two doses of penicillin G was not always followed. Of the 38 infants who were born 4 hours or less after the first dose, 18 received one dose, 11 received two doses and 9 received three or more doses.