Primary endpoint, impact of the time of initiation of antibiotic therapy on neonatal outcome
| Adjusted OR (95% CI) | P value | Hosmer and Lemeshow goodness-of-fit test | Nagelkerke R2 | |
| Outcome BPD | ||||
| Time of initiation of ABT | 0.12 | 0.30 | ||
| No ABT | 1 | |||
| ABT start, day 1 or 2 | 3.06 (1.36 to 6.88) | 0.01 | ||
| ABT start, days 3–6 | 2.79 (1.11 to 7.00) | 0.03 | ||
| ABT start, day ≥7 | 1.31 (0.39 to 4.37) | 0.66 | ||
| Outcome IVH | ||||
| Time of initiation of ABT | 0.74 | 0.21 | ||
| No ABT | 1 | |||
| ABT start, day 1 or 2 | 2.13 (1.07 to 4.25) | 0.03 | ||
| ABT start day, days 3–6 | 1.41 (0.57 to 3.48) | 0.46 | ||
| ABT start, day ≥7 | 3.07 (1.22 to 7.73) | 0.02 | ||
| Outcome death | ||||
| Time of initiation of ABT | 0.25 | 0.25 | ||
| No ABT | 1 | |||
| ABT start, day 1 or 2 | 2.54 (1.31 to 4.97) | 0.01 | ||
| ABT start, days 3–6 | 1.72 (0.71 to 4.16) | 0.23 | ||
| ABT start, day ≥7 | 3.13 (1.24 to 7.88) | 0.02 | ||
BPD: model adjusted by GA, antenatal steroids, base excess, SGA, Apgar score at 5 min, central line, tracheal ventilation, sepsis and NEC.
IVH: model adjusted by GA, antenatal steroids, Apgar score at 10 min, mode of birth, IAI, arterial line, tracheal ventilation and FIP surgery.
IVH: model adjusted by GA, antenatal steroids, Apgar score at 10 min, mode of birth, IAI, arterial line, tracheal ventilation and FIP surgery.
Bold type: significant adjusted OR are shown in bold.
ABT, antibiotic therapy; BPD, bronchopulmonary dysplasia; FIP, focal intestinal perforation; GA, gestational age; IAI, intra-amniotic infection; IVH, intraventricular haemorrhage; NEC, necrotising enterocolitis; SGA, small for gestational age.