Pathogen distribution in 582 late-onset sepsis (LOS) episodes and LOS-attributable mortality in 493 very preterm infants
| Culture-positive LOS episodes n=582 (%*) | LOS attributable death in 493 patients with a positive blood culture (%†) | |
| Gram positive bacteria, excl. CoNS | 183 (31.4) | 7/163 (4.3) |
| Staphylococcus aureus‡ | 89 (15.1) | 2 (2.2) |
| Group B streptococcus | 55 (9.5) | 2 (3.6) |
| Enteroccocus spp. | 24 (4.1) | 2 (8.3) |
| Bacillus spp. | 4 (0.7) | 1 (2.5) |
| Other | 11 (1.9) | 0 (0) |
| CoNS | 282 (48.5) | 9/224 (4.0) |
| Gram-negative bacteria | 105 (18.0) | 15/95 (15.8) |
| Escherichia coli | 49 (8.4) | 7 (14) |
| Klebsiella spp. | 26 (4.5) | 5 (19.2) |
| Enterobacter spp. | 18 (3.1) | 1 (5.6) |
| Serratia spp. | 4 (0.7) | 0 (0) |
| Other | 4 (0.7) | 0 (0) |
| Salmonella spp. | 2 (0.3) | 1 (50) |
| Pseudomonas spp. | 1 (0.2) | 1 (100) |
| Acinetobacter spp. | 1 (0.2) | 0 (0) |
| Candida spp. | 11 (1.9) | 0/11 (0) |
| Other | 1 (0.2) | 0 (0) |
| Total | 582 | 31/493 (6.3) |
LOS attributable death was defined as death within 7 days of positive blood culture.
* Percentage of all LOS cases.
†Percentage infants in each pathogen category.
‡Only one out of 89 S. aureus cases was methicillin resistant.
CoNS, coagulase-negative staphylococci.