1 | Does routine fortification of human milk feeds improve necrotising enterocolitis and long-term neurodevelopmental outcomes in preterm babies? | 7.305 |
2 | In preterm and term babies requiring resuscitation, does intact cord resuscitation improve survival and brain injury compared with standard resuscitation with early cord clamping? | 6.990 |
3 | In babies diagnosed with necrotising enterocolitis, does earlier surgical intervention improve survival, brain injury and quality of life compared with standard practice? | 6.959 |
4 | Does therapeutic hypothermia (cooling) reduce brain injury and improve general cognition in babies with mild hypoxic ischaemic encephalopathy compared with standard care? | 6.920 |
5 | In extremely preterm infants (<28 weeks’ gestation at birth), should we routinely use non-invasive positive pressure ventilation or continuous positive airway pressure as the primary mode of respiratory support to improve survival and reduce bronchopulmonary dysplasia? | 6.867 |
6 | Is early breastmilk fortification or late breastmilk fortification superior with regard to outcomes such as necrotising enterocolitis in preterm babies? | 6.857 |
7 | In preterm babies, do probiotics improve survival, sepsis and necrotising enterocolitis? | 6.838 |
8 | Does human-derived milk fortifier rather than bovine-derived milk fortifier improve outcomes such as necrotising enterocolitis in preterm babies? | 6.838 |
9 | In very preterm infants at delivery, does physiological-based cord clamping (ie, stabilisation or resuscitation with the cord intact and only clamping when heart rate is >100 beats/min and oxygen saturation >85% in an inspired oxygen concentration of <0.4) versus time-based clamping at 60 s (or earlier if stabilisation or resuscitation is needed) increase survival without disability? | 6.714 |
10 | In preterm infants with insufficient maternal milk available, does the use of pasteurised human milk (donor) as compared with preterm formula reduce necrotising enterocolitis requiring surgery and improve 2-year neurodevelopmental outcomes? | 6.705 |