Table 2

Alarcon scoring and hearing data of 48 children with cCMV and evaluable neuroimaging

Alarcon score	n	Neuroimaging				Hearing
Alarcon score	n	Modality	N	Abnormalities (n)		Normal	Unilateral SNHL	Bilateral SNHL
0 No abnormalities	8	cUS	6	None		1	5	2
		MRI	1
		Both	1
1 Mild abnormalities	34	cUS	18	Single calcifications (1), LSV (11), GLC (5), mild VM (8)		1	18	15
		MRI	2	Mild VM (1), (multi) focal WM signal abnormality (2)
		Both	14	cUS LSV (6) GLC (9) Single calcification (2) Mild VM (1)	MRI GLC (1) (Multi) focal WM signal abnormality (9)
2 Moderate abnormalities	3	cUS	0			0	1	2
		MRI	1	Mild VM, diffuse WM signal abnormality
		Both	2	cUS LSV (2) GLC (1)	MRI Severe VM (1) (Multi)focal WM signal abnormality (2) Temporal lobe involvement (2)
3 Severe abnormalities	3	cUS	0			0	1	2
		MRI	2	(Multi)focal WM signal abnormality (1) PMG (2)
		Both	1	cUS LSV Mild VM Extensive calcification Atrophy Suspected PMG Dysgenesis of CC	MRI Mild VM Diffuse WM signal abnormality PMG Dysgenesis of CC

Alarcon classification: 0=none of the following abnormalities; 1=single punctate periventricular calcification, LSV, caudothalamic germinolysis, VM (excluding severe) and/or focal/multifocal WM signal abnormality on MRI; 2=multiple discrete periventricular calcifications, paraventricular GLC, severe VM, diffuse WM signal abnormality and/or temporal lobe involvement; 3=extensive calcifications, brain atrophy, abnormal gyration, cortical malformation, dysgenesis of the CC and/or cerebellar hypoplasia.
CC, corpus callosum; cUS, cranial ultrasound; GLC, germinolytic cyst; LSV, lenticulostriate vasculopathy; PMG, polymicrogyria; SNHL, sensorineural hearing loss; VM, ventriculomegaly; WM, white matter.