Mortality | 30% Threshold | 40% Threshold | 50% Threshold | 60% Threshold | ||||

Studies: 14 Participants: 5290 | ||||||||

Prophylaxis: 123 per 1000 (12.3%) | OR 1.81 (1.00 to 3.44) Network estimate | 79 more per 1000 (0 fewer to 202 more) | OR 1.52 (0.94 to 2.40) Network estimate | 53 more per 1000 (7 fewer to 128 more) | OR 0.82 (0.50 to 1.41) Network estimate | 20 fewer per 1000 (57 fewer to 42 more) | OR 1.16 (0.63 to 2.29) Network estimate | 17 more per 1000 (41 fewer to 120 more) |

Quality of evidence: ⊕⊕◯◯ Low *† | Based on 1783 participants (3 RCTs) | Based on 1014 participants (5 RCTs) | Based on 1617 participants (3 RCTs) | Based on 876 participants (3 RCTs) |

*The trials all had some concerns or were at high risk of bias.

†There was significant heterogeneity.

‡This is a surrogate outcome or was an indirect comparison.

§Less than 300 events in combined groups.

¶There is evidence of publication bias.

RCT, randomised controlled trial.