Table 2

Summary of findings table for the primary outcome mortality at maximal follow-up

Mortality30% Threshold40% Threshold50% Threshold60% Threshold
Studies: 14
Participants: 5290
Prophylaxis:
123 per 1000
(12.3%)		OR 1.81
(1.00 to 3.44)
Network estimate		79 more per 1000
(0 fewer to 202 more)		OR 1.52
(0.94 to 2.40)
Network estimate		53 more per 1000
(7 fewer to 128 more)		OR 0.82
(0.50 to 1.41)
Network estimate		20 fewer per 1000
(57 fewer to 42 more)		OR 1.16
(0.63 to 2.29)
Network estimate		17 more per 1000
(41 fewer to 120 more)
Quality of evidence:
⊕⊕◯◯ Low *†		Based on 1783 participants
(3 RCTs)		Based on 1014 participants
(5 RCTs)		Based on 1617 participants
(3 RCTs)		Based on 876 participants
(3 RCTs)

  • *The trials all had some concerns or were at high risk of bias.

  • †There was significant heterogeneity.

  • ‡This is a surrogate outcome or was an indirect comparison.

  • §Less than 300 events in combined groups.

  • ¶There is evidence of publication bias.

  • RCT, randomised controlled trial.