Threshold 30% | Threshold 40% | Threshold 50% | Threshold 60% | |||||

Bronchopulmonary dysplasia Studies: 8 Participants: 3003 | ||||||||

Prophylaxis: 113 per 1000 (11.3%) | OR 1.39 (0.87 to 2.24) Network estimate | 38 more per 1000 (13 fewer to 109 more) | OR 0.77 (0.37 to 1.58) Network estimate | 24 fewer per 1000 (68 fewer to 55 more) | OR 0.93 (0.74 to 1.16) Network estimate | 7 fewer per 1000 (27 fewer to 16 more) | OR 1.02 (0.72 to 1.45) Network estimate | 2 more per 1000 (30 fewer to 43 more) |

Quality of evidence: ⊕◯◯◯ Very low *†‡ | Based on 279 participants (1 RCT) | Based on 460 participants (3 RCTs) | Based on 1469 participants (2 RCTs) | Based on 795 participants (2 RCTs) | ||||

Chronic lung disease Studies: 9 Participants: 2740 | ||||||||

Prophylaxis: 284 per 1000 (28.4%) | OR 1.48 (0.82 to 2.63) Network estimate | 86 more per 1000 (40 fewer to 227 more) | OR 1.05 (0.63 to 1.64) Network estimate | 10 more per 1000 (84 fewer to 110 more) | OR 4.08 (0.77 to 35.45) Network estimate | 334 more per 1000 (50 fewer to 650 more) | OR 0.59 (0.28 to 1.22) Network estimate | 94 fewer per 1000 (185 fewer to 42 more) |

Quality of evidence ⊕◯◯◯ Very low *†‡ | Based on 1504 participants (2 RCTs) | Based on 855 participants (4 RCTs) | Based on 153 participants (1 RCT) | Based on 228 participants (2 RCTs) | ||||

BPD or CLD Studies: 13 Participants: 5142 | ||||||||

Prophylaxis: 171 per 1000 (17.1%) | OR 1.45 (0.95 to 2.21) Network estimate | 59 more per 1000 (7 fewer to 142 more) | OR 0.91 (0.54 to 1.41) Network estimate | 13 fewer per 1000 (71 fewer to 54 more) | OR 0.96 (0.59 to 2.00) Network estimate | 6 fewer per 1000 (63 fewer to 121 more) | OR 0.86 (0.47 to 1.34) Network estimate | 21 fewer per 1000 (83 fewer to 45 more) |

Quality of evidence ⊕◯◯◯ Very low *†‡ | Based on 1783 participants (3 RCTs) | Based on 1014 participants (5 RCTs) | Based on 1469 participants (2 RCTs) | Based on 876 participants (3 RCTs) | ||||

Pneumothorax Studies: 14 Participants: 5290 | ||||||||

Prophylaxis 33 per 1000 (3.3%) | OR 2.41 (0.61 to 10.48) Network estimate | 43 more per 1000 (13 fewer to 232 more) | OR 1.26 (0.42 to 3.97) Network estimate | 8 more per 1000 (19 fewer to 87 more) | OR 0.81 (0.19 to 3.47) Network estimate | 6 fewer per 1000 (27 fewer to 74 more) | OR 2.05 (0.50 to 10.72) Network estimate | 33 more per 1000 (16 fewer to 237 more) |

Quality of evidence ⊕◯◯◯ Very low *†§ | Based on 1783 participants (3 RCTs) | Based on 1014 participants (5 RCTs) | Based on 1617 participants (3 RCTs) | Based on 876 participants (3 RCTs) |

All results are reported as OR with 95% credible intervals.

*The trials were all had some concerns or were at high risk of bias.

†There was significant heterogeneity.

‡This is a surrogate outcome or was an indirect comparison.

§Less than 300 events in combined groups.

RCT, randomised controlled trial.