Entire cohort (n=431) | SARS-CoV-2 ≤2 weeks prior to delivery (n=261) | SARS-CoV-2 >2 weeks prior to delivery (n=163) | P value | |
Gestational age at birth | 39.4±2.0 | 39.3±2.2 | 39.6±1.7 | n.s. |
Preterm, n (%) | 56/431 (13.0) | 39/261 (14.9) | 17/163 (10.4) | n.s. |
Delivered vaginally, n (%) | 267/431 (62.0) | 161/260 (61.9) | 103/163 (63.2) | n.s. |
Caesarean section, maternal indication due to SARS-CoV-2, n (%) | 8/163 (4.9) | 8/99 (8.1) | 0/60 (0) | 0.07 |
Birth weight, g, n (%) | n.s. | |||
500–999 | 1/427 (0.2) | 1/259 (0.4) | 0/161 (0) | |
1000–1499 | 3/427 (0.7) | 3/259 (1.2) | 0/161 (0) | |
1500–1999 | 5/427 (1.2) | 3/259 (1.2) | 2/161 (1.2) | |
2000–2499 | 25/427 (5.9) | 15/259 (5.8) | 10/161 (6.2) | |
2500–2999 | 64/427 (15.0) | 39/259 (15.1) | 24/161 (14.9) | |
3000–3499 | 169/427 (39.6) | 104/259 (40.2) | 61/161 (37.9) | |
3500–3999 | 128/427 (30.0) | 73/259 (28.2) | 53/161 (32.9) | |
4000–4499 | 29/427 (6.8) | 20/259 (7.7) | 9/161 (5.6) | |
>4500 | 3/427 (0.7) | 1/259 (0.4) | 2/161 (1.2) | |
Apgar | n.s. | |||
5 min Apgar <6, n (%) | 5/422 (1.2) | 4/255 (1.6) | 1/161 (0.6) | |
Cord pH | 7.26±0.09 | 7.26±0.09 | 7.26±0.1 | n.s. |
Congenital malformations, n (%) | 9/428 (2.11) | 5/259 (1.9) | 4/161 (2.5) | n.s. |
NICU admission, n (%) | 60/427 (14) | 40/260 (15.4) | 20/160 (12.5) | n.s. |
Reason for NICU admission, n (%) | n.s. | |||
Prematurity | 20/58 (34.5) | 14/38 (36.8) | 6/20 (30.0) | |
Respiratory distress | 16/58 (27.6) | 9/38 (23.7) | 7/20 (35.0) | |
Asphyxia | 4/58 (6.9) | 3/38 (7.9) | 1/20 (5.0) | |
Connatal infection | 7/58 (12.1) | 6/38 (15.8) | 1/20 (5.0) | |
Small-for-gestational-age | 3/58 (5.2) | 0/38 (0) | 3/20 (15) | |
Maternal COVID-19 | 4/58 (6.9) | 3/38 (7.9) | 1/20 (5) | |
Others | 4/58 (6.9) | 3/38 (7.9) | 1/20 (5) | |
Ventilation, n (%) | 0.07 | |||
Intubation | 3/51 (5.9) | 3/34 (8.8) | 0/17 (0) | |
Nasal continuous positive airway pressure | 20/51 (39.2) | 15/34 (44.1) | 5/17 (26.4) | |
High-flow cannula | 1/5 (2.0) | 1/34 (2.9) | 0/17 (0) | |
Supplemental oxygen | 3/51 (5.9) | 1/34 (2.9) | 2/17 (11.8) | |
Rooming-in, n (%) | 367/417 (85.5) | 219/255 (85.9) | 141/155 (91.0) | 0.11 |
Mother’s own milk feeding, n (%) | 385/415 (92.8) | 232/252 (92.1) | 147/156 (94.2) | 0.11 |
SARS-CoV-2 PCR positive, n (%) | 9/323 (2.8) | 9/198 (4.5) | 0/120 (0) | 0.08 |
Antibodies positive, n (%) | 29/119 (24.4) | 3/71 (4.2) | 26/47 (55.3) | <0.0001 |
NICU, neonatal intensive care unit.