EPICure 1995 | EPICure2 2006 | Difference in means (95% CI) 2006 vs 1995 | ||||
Mean (SD) | Median (IQR) | Mean (SD) | Median (IQR) | Unadjusted | Adjusted* | |
EP children | 0.77 (0.28) (n=140) | 0.87 (0.70–0.97) | 0.65 (0.35) (n=88) | 0.76 (0.38–0.97) | −0.12 (−0.20 to –0.04) | −0.27 (−0.41 to –0.12) |
EP children after excluding those with severe impairment | 0.83 (0.21) (n=122) | 0.91 (0.77–1.00) | 0.75 (0.28) (n=66) | 0.86 (0.65–0.97) | −0.08 (−0.15 to –0.01) | −0.14 (−0.26 to –0.01) |
Controls | 0.96 (0.10) (n=141) | 1.00 (0.95–1.00) | 0.95 (0.12) (n=120) | 1.00 (0.93–1.00) | −0.01 (−0.04 to 0.02) | – |
Bold font indicates significant changes over time.
*Adjusted for significant differences between the two cohorts, including ethnicity (white, black, South Asian or other), maternal education (low, medium or high), maternal age at birth, any breast milk (yes or no), enteral feeding by day 7 (yes vs no), postnatal systemic steroids (yes vs no) and exact age at the 11-year assessment.
EP, extremely preterm; HUI, Health Utilities Index.