Table 3

Clinical and diagnostic characteristics of neonates with HSV infection in Germany 2017–2018

Category of diseaseNumber of infants*
 Not reported2
Clinical symptoms
 No symptoms10
 Mucocutaneous herpes blisters10
 Poor feeding7
 Circulatory problems7
 Body temperature >38.0°C5
 Dyspnoea or tachypnoea6
 Unspecific symptoms6
Laboratory findings
 No abnormal findings21
 Elevated liver enzymes10
 Leucocyte count >15/nL7
 Thrombocytopenia <150/nL5
 Abnormal coagulation4
 CRP >15 mg/L4
 CSF cell count >20/nL (0–28 DOL), >9/nL (29–60 DOL)3
 CSF glucose <40 mg/dL2
 Leucocyte count <5/nL1
Cranial ultrasound
 Not performed/unknown10
Cranial MRI
 Not performed29
 Not performed29
  • *Multiple answers possible.

  • CNS, central nervous system; CRP, C reactive protein; CSF, cerebrospinal fluid; DOL, day of life; EEG, electroencephalogram; HSV, herpes simplex virus.