Brain volume measurements (and weighted means) in preterm infants at term-equivalent age
| N | PMA at scan (weeks) Mean (SD) | Total brain volume (mL) Mean (SD) | Total cerebellar volume (mL) mean (SD) | Cortical grey matter volume (mL) Mean (SD) | Unmyelinated white matter volume (mL) Mean (SD) | |
| Blok et al, 201420 | 36 | 41.4 (0.8) | 391 (34) | N/A |
167 (23)*
(overlap with Moeskops et al 21 |
161 (21)*
(overlap with Moeskops et al 21) |
| Ekblad et al, 201030 | 209 | † | 397 (51.2) | 24.2 (5.1) | N/A | N/A |
| Hansen-Pupp et al, 201122 | 51 | 40.1 (0.6) |
396 (46.3)*
(n=46, overlap with Hansen-Pupp et al 23) | 21.3 (2.7) | N/A |
191 (25)*
(n=46, overlap with Hansen-Pupp et al 23) |
| Hansen-Pupp et al, 201323 | 49 | 40.1 (0.6) | 393 (50.9) |
21.1 (3.5)*
(overlap with Hansen-Pupp et al 22) | N/A | 190 (25) |
| Inder et al, 20058 | 119 | 40.2 (0.3) | 406 (57) | N/A | 178 (41) | 202 (41) |
| Kamino et al, 2018 28 | 44 | 37.7 (3.0) | N/A | 16.7 (5.3) | 107.6 (40.2) | 151 (20.1) |
| Moeskops et al, 201521 | 85 | 41.1 (0.5) | N/A | N/A | 107 (13) | 171 (19) |
| Parikh et al, 201329 | 122 | 38.5 (2.2) | 270 (41.5) | 16.1 (4.2) | 105 (19.1) | N/A |
| Steinhorn et al, 201524 | 192 | ‡ | 395 (63.2)* (overlap with Thompson et al 25) | 21.4 (4.5) |
159 (41)*
(overlap with Thompson et al 25) | N/A |
| Stiver et al, 2015 26 | 105 | 41.9 (2.0) | N/A | 23.9 (5) | N/A | N/A |
| Tam et al, 201127 | 68 | 39.5 (1.3) | N/A | 20.4 (5) | N/A | N/A |
| Thompson et al, 2007 25 | 202 | 40.1 (1.7) | 395 (64) | N/A | 159 (41) | 212 (32) |
| Vasu et al, 2014 31 | 19 | 40.2 (3.1) | 462 (12.8) | N/A | N/A | N/A |
| Aggregate data all studies Weighted mean (√(Total variance)) | 379 (72); n=756 | 21 (6); n=791 | 140 (47); n=572 | 195 (38); n=499 | ||
| Aggregate data all studies Mean (SD) by simulation | 391 (67)§ | 19 (5)§ | 135 (68)§ | 192 (38)§ | ||
| Aggregate data excluding reference29
Weighted mean (√(Total variance)) | 399 (57) n=634 | 22.3 (5.3) n=669 | 149.2 (47.8) n=450 | N/A | ||
*Not included in the meta-analysis.
†According to personal communication with the author: ‘MRI were performed at term (SD 5 days) in 93% of infants. The time between term age and imaging day was at most 29 days (in one infant).’ Out of 232 total MRI scans, 209 were successfully performed and analysed.
‡Between 38 and 42 weeks.
§Adjusted R2 for TBV 0.9850, for CV 0.9965, for CGM 0.8822, for UMWM 0.9906.
CGM, cortical grey matter; CV, cerebellar volume; N/A, not available; PMA, postmenstrual age; TBV, total brain volume; UMWM, unmyelinated white matter.