Outcome variable | Born in non-CC | Born in CC | OR (95% CI) | P value |
n=2165* | n=2165* | |||
Survival without seizures | 693 (31.8) | 764 (35.1) | 1.15 (1.02 to 1.31) | 0.02 |
Seizures | 1399 (64.6) | 1314 (60.7) | 0.84 (0.75 to 0.95) | 0.007 |
Death | 312 (14.4) | 343 (15.8) | 1.11 (0.93 to 1.31) | 0.2 |
Day of death (hours) | ||||
<24 | 65 (3.0) | 81 (3.7) | – | 0.06 |
24–72 | 87 (4.0) | 116 (5.4) | 1.08 (0.70 to 1.66) | |
>72 | 160 (7.4) | 145 (6.7) | 0.72 (0.49 to 1.08) | |
Anticonvulsants†‡ | ||||
None | 349 (25.0) | 296 (22.5) | – | – |
1 drug | 668 (47.3) | 663 (50.5) | 1.17 (0.96 to 1.42) | 0.1 |
≥2 drugs | 382 (27.2) | 355 (27.0) | 1.09 (0.88 to 1.36) | 0.4 |
Respiratory support† | ||||
Ventilated | 1454 (67.2) | 1515 (70.0) | 1.15 (0.94 to 1.42) | 0.17 |
HFOV | 388 (17.9) | 340 (15.7) | 0.97 (0.76 to 1.24) | 0.81 |
CPAP | 95 (4.4) | 104 (4.8) | 1.21 (0.85 to 1.72) | 0.28 |
Hypotension | 983 (45.4) | 982 (45.4) | 0.99 (0.88 to 1.12) | 0.96 |
PPHN | 260 (12.0) | 236 (10.9) | 0.90 (0.74 to 1.08) | 0.25 |
Nitric oxide | 214 (9.9) | 236 (10.1) | 1.02 (0.84 to 1.25) | 0.79 |
Length of stay (days) | 11.3 (7.3–18.9) | 10.0 (6.5–16.4) | 0.14 (0.05 to 0.36) | <0.001 |
*Data are n (%) or median (IQR).
†Compared with baseline – no anticonvulsant/No respiratory support.
‡Data are n (%) of infants with seizures.
CC, cooling centre; CPAP, continuous positive airway pressure; HFOV, high frequency oscillatory ventilation; PPHN, persistent pulmonary hypertension.