Table 2

Outcomes of infants with moderate or severe hypoxic-ischaemic encephalopathy who were born in either a non-CC or CC after propensity score matching

Outcome variableBorn in non-CCBorn in CCOR (95% CI)P value
n=2165*n=2165*
Survival without seizures693 (31.8)764 (35.1)1.15 (1.02 to 1.31)0.02
Seizures1399 (64.6)1314 (60.7)0.84 (0.75 to 0.95)0.007
Death312 (14.4)343 (15.8)1.11 (0.93 to 1.31)0.2
Day of death (hours)
 <2465 (3.0)81 (3.7)0.06
 24–7287 (4.0)116 (5.4)1.08 (0.70 to 1.66)
 >72160 (7.4)145 (6.7)0.72 (0.49 to 1.08)
Anticonvulsants†‡
 None349 (25.0)296 (22.5)
 1 drug668 (47.3)663 (50.5)1.17 (0.96 to 1.42)0.1
 ≥2 drugs382 (27.2)355 (27.0)1.09 (0.88 to 1.36)0.4
Respiratory support†
 Ventilated1454 (67.2)1515 (70.0)1.15 (0.94 to 1.42)0.17
 HFOV388 (17.9)340 (15.7)0.97 (0.76 to 1.24)0.81
 CPAP95 (4.4)104 (4.8)1.21 (0.85 to 1.72)0.28
Hypotension983 (45.4)982 (45.4)0.99 (0.88 to 1.12)0.96
PPHN260 (12.0)236 (10.9)0.90 (0.74 to 1.08)0.25
Nitric oxide214 (9.9)236 (10.1)1.02 (0.84 to 1.25)0.79
Length of stay (days)11.3 (7.3–18.9)10.0 (6.5–16.4)0.14 (0.05 to 0.36)<0.001
  • *Data are n (%) or median (IQR).

  • †Compared with baseline – no anticonvulsant/No respiratory support.

  • ‡Data are n (%) of infants with seizures.

  • CC, cooling centre; CPAP, continuous positive airway pressure; HFOV, high frequency oscillatory ventilation; PPHN, persistent pulmonary hypertension.