Table 4

Outcomes of infants with moderate or severe hypoxic-ischaemic encephalopathy who were born in either a level 2 non-CC or CC after propensity score-matching

Outcome variableBorn in non-CCBorn in CCOR (95% CI)P value
n=696*n=696*
Survival without seizures225 (32.3)270 (38.8)1.33 (1.06 to 1.65)0.01
Seizures445 (63.9)401 (57.6)0.77 (0.61 to 0.95)0.02
Death105 (15.1)90 (12.9)0.84 (0.62 to 1.13)0.25
Day of death (hours)
 ≤2425 (3.6)22 (3.2)0.84
 24–7228 (4.0)27 (3.9)1.10 (0.50 to 2.40)
 >7252 (7.5)41 (5.9)0.90 (0.44 to 1.82)
Anticonvulsants†‡
 None97 (21.8)116 (28.9)
 1 drug222 (49.9)206 (51.4)0.90 (0.71 to 1.13)0.67
 ≥2 drugs126 (28.3)79 (19.7)0.57 (0.42 to 0.78)<0.01
Respiratory support†
 Ventilated493 (70.8)454 (65.2)0.92 (0.64 to 1.32)0.66
 HFOV108 (15.5)145 (20.8)1.34 (0.88 to 2.04)0.17
 CPAP29 (4.2)30 (4.3)1.03 (0.56 to 1.91)0.91
Hypotension326 (46.8)303 (43.5)0.88 (0.71 to 1.08)0.22
PPHN97 (13.9)95 (13.8)0.98 (0.72 to 1.32)0.88
Nitric oxide66 (9.5)67 (9.6)1.01 (0.71 to 1.45)0.93
Transferred L2–L3615 (88.4)449 (64.5)0.24 (0.18 to 0.32)<0.001
Length of stay (days)10.6 (7.0–17.5)10.5 (6.8–17.7)0.55 (0.13 to 2.40)0.41
  • *Data are n (%).

  • †Compared with baseline − no anticonvulsants/no respiratory support.

  • ‡Data are n (%) of infants with seizures.

  • CC, cooling centre; CPAP, continuous positive airway pressure; HFOV, high frequency oscillatory ventilation; PPHN, persistent pulmonary hypertension.