Analysis of outcome variables for babies received vs did not receive parenteral nutrition
| Variable | Intervention | Difference (95% CI) | OR estimate (95% CI) | P value | |
| No parenteral nutrition (95% CI) | Parenteral nutrition (95% CI) | ||||
| N | 1240 | 1240 | |||
| Blood culture positive late onset infection, % | 0.3 (0.1 to 0.5) | 0.9 (0.4 to 1.4) | 0.6 (0.1 to 1.2) | 3.04 (0.95 to 9.76) | 0.03* |
| Late onset infection (pragmatic definition), % | 25.3 (23.6 to 27.1) | 26.1 (23.8 to 28.3) | 0.8 (−2.1 to 3.6) | 1.04 (0.87 to 1.25) | 0.61 |
| NEC (pragmatic definition), % | 1.4 (0.9 to 1.9) | 1.1 (0.6 to 1.6) | −0.3 (−1.0 to 0.4) | 0.77 (0.38 to 1.58) | 0.39 |
| Hypoglycaemia, % | 19.0 (17.5 to 20.6) | 17.0 (15.1 to 18.9) | −2.1 (−4.5 to 0.4) | 0.87 (0.71 to 1.07) | 0.10 |
| Survival at discharge, % | 90.0 (88.8 to 91.2) | 93.1 (91.8 to 94.4) | 3.1 (1.5 to 4.7) | 1.50 (1.17 to 2.01) | <0.001 |
| Breast feeding at discharge, % | 47.0 (45.1 to 48.9) | 46.4 (43.9 to 48.9) | −0.6 (−3.8 to 2.6) | 0.98 (0.83 to 1.14) | 0.71 |
| Length of stay, days | 14.1 (13.6 to 14.7) | 15.0 (14.1 to 15.8) | 0.8 (−0.2 to 1.8) | 0.12 | |
| First suckling at breast, days | 8.4 (8.0 to 8.7) | 8.6 (8.0 to 9.1) | 0.2 (−0.5 to 0.8) | – | 0.56 |
| First maternal milk, days | 4.9 (4.8 to 4.9) | 4.6 (4.5 to 4.8) | −0.2 (−0.4 to 0.1) | – | 0.01 |
| Duration of CV line, days | 5.1 (5.0 5.3) | 6.0 (5.7 to 6.3) | 0.9 (0.5 to 1.2) | – | <0.001 |
| Weight Z-score | −0.66 (−0.71 to 0.61) | −0.65 (−0.71 to –0.58) | 0.02 (−0.07 to 0.10) | – | 0.68 |
Results averaged over the 25 replications of the matching procedure.
CV, central venous; N, number; NEC, necrotising enterocolitis; NNAP, National Neonatal Audit Programme.