Preductal right carotid arterial blood gas parameters in the study groups
| Parameter | Spontaneous ROSC (n=10) | 0.01 mg/kg epinephrine-low flush (n=6) | 0.01 mg/kg epinephrine-high flush (n=6) | 0.03 mg/kg epinephrine-low flush (n=7) | 0.03 mg/kg epinephrine-high flush (n=9) |
| After arrest and prior to resuscitation | |||||
| pH | 6.86 (0.07) | 6.89 (0.11) | 6.85 (0.06) | 6.88 (0.07) | 6.86 (0.08) |
| PaCO2 (mm Hg) | 137 (16) | 113 (6) | 124 (22) | 142 (16) | 129 (24) |
| PaO2 (mm Hg) | 6 (4) | 7 (4) | 13 (7) | 6 (3) | 8 (4) |
| Lactate (mmol/L) | 10.5 (3.5) | 11.4 (2.9) | 9.3 (2.3) | 10.1 (1.3) | 9.7 (2.4) |
| At ROSC | n=10 | n=2 | n=2 | n=5 | n=9 |
| pH | 6.89 (0.09) | 6.81 (0.28) | 6.86 (0.06) | 6.98 (0.11) | 6.83 (0.10) |
| PaCO2 (mm Hg) | 103 (14) | 78 (18) | 81 (31) | 75 (24) | 97 (33) |
| PaO2 (mm Hg) | 34 (10) | 40 (2) | 89 (110) | 290 (232) | 89 (85) |
| FiO2 | 0.93 (0.22) | 1 (0) | 0.74 (0.46) | 1 (0) | 1 (0) |
| Lactate (mmol/L) | 12.6 (3.6) | 16.8 (4.5) | 9.4 (2.8) | 12.4 (2.2) | 11.0 (2.9) |
| 1 min after ROSC | n=8 | n=2 | n=2 | n=5 | n=9 |
| pH | 6.89 (0.10) | 6.86 (0.17) | 6.85 (0.09) | 7.04 (0.21) | 6.84 (0.07) |
| PaCO2 (mm Hg) | 105 (21) | 61 (12) | 87 (31) | 66 (41) | 105 (32) |
| PaO2 (mm Hg) | 46 (47) | 132 (65) | 145 (135) | 308 (224) | 226 (184) |
| FiO2 | 0.55 (0.33) | 0.61 (0.56) | 0.67 (0.41) | 0.94 (0.09) | 0.62 (0.39) |
| Lactate (mmol/L) | 12 (3.8) | 17.4 (5) | 9.5 (3.2) | 12.7 (3) | 11.8 (2.8) |
| 5 min after ROSC | n=10 | n=2 | n=2 | n=5 | n=9 |
| pH | 6.95 (0.15) | 6.93 (0.36) | 6.85 (0.08) | 7.15 (0.22) | 6.94 (0.13) |
| PaCO2 (mm Hg) | 88 (31) | 55 (21) | 85 (21) | 53 (40) | 83 (47) |
| PaO2 (mm Hg) | 69 (55) | 91 (61) | 97 (69) | 202 (140) | 98 (62) |
| FiO2 | 0.59 (0.33) | 0.26 (0.07) | 0.44 (0.20) | 0.58 (0.39) | 0.33 (0.26) |
| Lactate (mmol/L) | 11.7 (4.2) | 16.2 (5.4) | 9.5 (3.3) | 11.8 (2) | 10.9 (2.8) |
| 10 min after ROSC | n=10 | n=2 | n=2 | n=5 | n=8 |
| pH | 7.11 (0.16) | 7.01 (0.33) | 7.06 (0.04) | 7.20 (0.20) | 7.10 (0.19) |
| PaCO2 (mm Hg) | 54 (24) | 43 (13) | 45 (10) | 44 (33) | 63 (42) |
| PaO2 (mm Hg) | 126 (99) | 101 (33) | 100 (19) | 117 (56) | 102 (26) |
| FiO2 | 0.49 (0.31) | 0.26 (0.64) | 0.30 (0.13) | 0.45 (0.35) | 0.33 (0.25) |
| Lactate (mmol/L) | 11.2 (4.4) | 15.9 (5.8) | 8.9 (3.4) | 11.5 (1.9) | 10.4 (2.7) |
Low flush=1 mL flush (~0.25–0.27 mL/kg), high flush=3 mL/kg (≈10–12 mL) flush.
The variables were not statistically differently distributed among the groups (Kruskal-Wallis).
Data are represented as mean (SD).
ROSC, return of spontaneous circulation.