Table 5

Secondary outcomes

Standard (n=29)
n (%)*
Restrictive (n=29)
n (%)*
Odds ratio (95% CI)†P Value†
Mortality6 (21)7 (24)0.82 (0.24 to 2.83)0.75
Severe ultrasound abnormality5 (17)5 (17)1.00 (0.26 to 3.91)1
Grade 3/4 IVH5 (17)2 (7)3.06 (0.51 to 18.41)0.22
PVL2 (7)2 (7)1.04 (0.13 to 8.37)0.97
Any ultrasound abnormality16 (55)13 (45)1.51 (0.54 to 4.26)0.43
NEC1 (3)4 (14)0.22 (0.02 to 2.13)0.19
SIP3 (10)3 (10)1.00 (0.18 to 5.42)1
BPD‡17 (74)14 (64)1.87 (0.45 to 7.68)0.39
Duration of inotrope (hours)17.8 (7.5–30.6)§¶13.7 (6.1–24.5)§**1.46 (0.84 to 2.56)††0.18
Any intervention11 (38)19 (66)0.32 (0.11 to 0.94)0.038
  • *Unless otherwise stated.

  • †From logistic regression analysis unless otherwise stated.

  • ‡Of those who had survived to 36 weeks.

  • §Median (IQR).

  • ¶n=21 in the standard group.

  • **n=22 in the restricted group.

  • ††Ratio of geometric means as the duration variable was log-transformed.

  • BPD, bronchopulomary dysplasia; IVH, intraventricular haemorrhage; NEC, necrotising enetrocolitis; PVL, periventricular leucomalacia; SIP, spontaneous intestinal perforation.