Table 2

Predictive ability of MRI abnormalities and general movements assessment for adverse outcome*

SensitivitySpecificityPPVNPVAccuracy
Moderately/Severely abnormal MRI†61.5 (31.6 to 86.1)90.0 (73.5 to 97.9)72.7 (45.6 to 89.5)84.4 (72.9 to 91.6)81.4 (66.6 to 91.6)
Moderate/Severe BGT injury61.5 (31.6 to 86.1)96.7 (82.8 to 99.9)88.9 (52.6 to 98.3)85.3 (74.4 to 92.1)86.1 (72.1 to 94.7)
Absent PLIC46.2 (19.2 to 74.9)100.0 (88.4 to 100.0)100.081.1 (72.2 to 87.6)83.7 (69.3 to 93.2)
Equivocal/Absent PLIC76.9 (46.2 to 95.0)93.3 (77.9 to 99.2)83.3 (55.9 to 95.2)90.3 (77.5 to 96.2)88.4 (74.9 to 96.1)
Absent FMs60.0 (26.2 to 87.8)89.3 (71.8 to 97.7)66.7 (38.0 to 86.7)86.2 (74.3 to 93.1)81.6 (65.7 to 92.3)
Sporadic or absent FMs70.0 (34.8 to 93.3)57.1 (37.2 to 75.5)36.8 (24.4 to 51.3)84.2 (66.3 to 93.6)60.5 (43.4 to 76.0)
  • Data are % (95% CI).

  • *Adverse outcome defined as death, cerebral palsy with Gross Motor Function Classification System level 3–5 or Bayley-III cognitive and/or motor composite score <85.

  • †Moderately/Severely abnormal MRI defined as moderate/severe BGT score and/or absent PLIC and/or severe WM score.

  • BGT, basal ganglia and thalami; FMs, fidgety movements; NPV, negative predictive value; PLIC, posterior limb of the internal capsule; PPV, positive predictive value.