Table 2

Univariable and multivariable generalised linear mixed models for the associations between neonatal hyperglycaemia (>8 and >10 mmol/L) and moderate to severe neurodevelopmental disability at 6.5 years of age in children born extremely preterm

Hyperglycaemia definitionModerate to severe NDDCrude OR (95% CI)P valueaOR (95% CI)P value
No hyperglycaemiaHyperglycaemia
>8 mmol/Lat least once12/56 (21.4%)132/380 (34.7%)1.95 (0.99 to 3.84)0.0551.27 (0.60 to 2.67)0.532
on ≥2 consecutive days40/160 (25.0%)104/276 (37.7%)1.81 (1.17 to 2.81)0.0081.16 (0.68 to 1.97)0.588
on ≥3 consecutive days68/252 (27.0%)76/184 (41.3%)1.90 (1.26 to 2.87)0.0021.36 (0.83 to 2.24)0.226
Days with hyperglycaemia (per 1-day increase)1.07 (1.04 to 1.10)<0.0011.03 (0.99 to 1.08)0.176
>10 mmol/Lat least once37/138 (26.8%)107/298 (35.9%)1.53 (0.97 to 2.40)0.0661.08 (0.63 to 1.87)0.775
on ≥2 consecutive days76/251 (30.3%)68/185 (36.8%)1.34 (0.89 to 2.01)0.1650.88 (0.53 to 1.48)0.637
on ≥3 consecutive days91/319 (28.5%)53/117 (45.3%)2.07 (1.33 to 3.23)0.0011.42 (0.82 to 2.45)0.214
Days with hyperglycaemia (per 1-day increase)1.08 (1.04 to 1.13)<0.0011.04 (0.98 to 1.10)0.178
  • A random intercept was used to account for the clustering effect of twins/triplets. Adjusted for gestational age at birth, sex, occurrence of intraventricular haemorrhage grade 3–4 and/or periventricular leukomalacia, durations of mechanical ventilation and steroid treatments during the first 14 postnatal days, surgery due to patent ductus arteriosus or necrotising enterocolitis during the first 14 postnatal days, number of culture-verified sepsis episodes during the first 14 postnatal days and educational status of the mother.

  • NDD, neurodevelopmental disability.