Table 3

Univariable and multivariable generalised linear mixed models for the associations between neonatal hyperglycaemia (>8 and >10 mmol/L) and survival without moderate to severe neurodevelopmental disability at 6.5 years of age in children born extremely preterm

Hyperglycaemia definitionSurvival without moderate to severe NDDCrude OR (95% CI)P valueaOR (95% CI)P value
No hyperglycaemiaHyperglycaemia
>8 mmol/Lat least once44/73 (60.3%)249/460 (54.1%)0.78 (0.46 to 1.31)0.3510.87 (0.49 to 1.55)0.628
on ≥2 consecutive days120/184 (65.2%)173/338 (51.2%)0.56 (0.38 to 0.82)0.0031.16 (0.74 to 1.82)0.517
on ≥3 consecutive days185/281 (65.8%)108/229 (47.2%)0.46 (0.32 to 0.67)<0.0011.54 (0.99 to 2.38)0.056
Days with hyperglycaemia (per 1-day increase)0.96 (0.93 to 0.99)0.0031.00 (0.96 to 1.04)0.965
>10 mmol/Lat least once102/164 (62.2%)191/369 (51.8%)0.66 (0.45 to 0.96)0.0341.13 (0.71 to 1.78)0.606
on ≥2 consecutive days176/291 (60.5%)117/231 (50.6%)0.67 (0.47 to 0.96)0.0311.03 (0.66 to 1.59)0.913
on ≥3 consecutive days229/362 (63.3%)64/148 (43.2%)0.44 (0.30 to 0.66)<0.0011.47 (0.91 to 2.39)0.115
Days with hyperglycaemia (per 1-day increase)0.94 (0.90 to 0.97)0.0011.02 (0.97 to 1.07)0.400
  • A random intercept was used to account for the clustering effect of twins/triplets. Adjusted for gestational age at birth, sex, occurrence of intraventricular haemorrhage grade 3–4 and/or periventricular leukomalacia, durations of mechanical ventilation and steroid treatments during the first 14 postnatal days, surgery due to patent ductus arteriosus or necrotising enterocolitis during the first 14 postnatal days, number of culture-verified sepsis episodes during the first 14 postnatal days and educational status of the mother.

  • NDD, neurodevelopmental disability.