Table 2

Primary outcome

Variablen (DRIFT:standard)DRIFT
Mean (SD) or n (%)
Standard
Mean (SD) or n (%)
Crude difference (95% CI), p valueAdjusted difference (95% CI), p value*
Primary outcome
Cognitive ability quotient27:2469.33 (30.06)53.68 (35.70)15.65 (−2.86 to 34.16), 0.096†23.47 (6.23 to 40.71), 0.009†
Sensitivity analyses
Cognitive ability quotient‡29:2664.55 (34.04)49.55 (37.22)15.00 (−4.28 to 34.27), 0.125†22.33 (4.77 to 39.89), 0.014†
Alive and without severe cognitive disability§29:2621 (72%)11 (42%)3.58 (1.16 to 11.04), 0.026¶9.96 (2.12 to 46.67), 0.004¶
Alive and without severe cognitive disability**32:3121 (66%)11 (35%)3.47 (1.23 to 9.78), 0.019¶7.69 (1.96 to 30.11), 0.003¶
  • *Adjusted for sex, birth weight and grade of IVH.

  • †Linear regression (difference in means).

  • ‡Giving children who have died post 2 years a score of 0.

  • §Including all 4 deaths after 2 years as a negative outcome.

  • ¶Logistic regression (OR).

  • **Including all 12 deaths as a negative outcome (akin to the study results at 2 years).

  • DRIFT, drainage, irrigation and fibrinolytic therapy; IVH, intraventricular haemorrhage.