Table 1

Characteristics of participants assessed at 10 years by trial allocation

nDRIFTnStandard
Mean (SD) or n (%)Mean (SD) or n (%)
Total number of participants2824
Centre
Bristol, UK28 Embedded Image 23 (82%)24 Embedded Image 19 (79%)
Katowice, Poland3 (11%)4 (17%)
Glasgow, UK1 (4%)1 (4%)
Bergen, Norway1 (4%)0 (0%)
Sociodemographics at birth
Age at randomisation (days)2818.68 (5.00)2419.17 (4.53)
Sex: male*2822 (79%)2415 (63%)
Clinical characteristics at birth
Birth weight (g)*281101.89 (335.54)241322.46 (534.68)
Gestation (weeks)2827.64 (2.56)2428.50 (3.05)
Grade of IVH: 42814 (50%)2411 (46%)
Maternal age at birth1428.50 (6.99)1228.17 (6.32)
Median IMD 2010, postcode at birth† (IQR)1826.7 (8.2–36.5)1827.6 (11.2–45.8)
Measures at 2 years
Experienced second IVH*288 (29%)243 (13%)
VP shunt2811 (39%)248 (33%)
Ventricular access device*2813 (46%)2419 (79%)
Measures at 10 years
Age at 10-year assessment (years)2810.56 (1.07)2410.76 (1.06)
Weight (kg)2835.41 (10.05)2334.73 (10.51)
Height (cm)28139.09 (12.22)23142.26 (11.34)
Head circumference (cm)2852.88 (2.53)2352.00 (3.43)
Maternal education*
Left school at 1628 Embedded Image 10 (36%)23 Embedded Image 11 (48%)
Further education6 (21%)5 (22%)
University degree12 (43%)7 (30%)
  • *Difference of 10%/0.5 SD or higher between the groups.

  • †English Index of Multiple Deprivation (IMD) 2010 scores, UK Data Service Census Support (http://geoconvert.mimas.ac.uk/). Higher scores indicate higher levels of deprivation. IMD based on the children’s home postcode at birth for those residing in England only.

  • DRIFT, drainage, irrigation and fibrinolytic therapy; IVH, intraventricular haemorrhage; VP, ventriculoperitoneal.