Table 2

Characteristics associated with loss to follow-up at 2 years corrected age: EPICE cohort

Characteristics	Non-responders		Responders		P value	P value*
Characteristics	N	%	N	%	P value	P value*
Mother, pregnancy, delivery	1633		2739
Maternal age (years)
≤24	419	25.8	323	11.8	<0.001	<0.001
25–34	842	51.8	1573	57.6
≥35	364	22.4	835	30.6
Parity first child	812	50.0	1651	60.6	<0.001	<0.001
Multiple pregnancy	275	16.9	533	19.5	0.03	0.02
PPROM	433	27.4	665	24.7	0.05	0.03
Pre-eclampsia/eclampsia/HELLP	273	17.3	472	17.4	0.92	0.71
Received antenatal steroids	1440	89.1	2474	91.0	0.03	0.14
Born in the country†	649	66.8	1815	84.5	<0.001	<0.001
Infant, postneonatal care, morbidity	1920		3294
Gestational age at birth (weeks)
23–25	166	8.7	263	8.0	0.02	0.14
26–27	275	14.3	580	17.6
28–29	517	26.9	859	26.1
30–31	961	50.1	1592	48.3
Birth weight – less than 750 g	151	7.9	285	8.7	0.32	0.40
Male	1038	54.1	1754	53.3	0.56	0.94
SGA
<3rd percentile	380	19.8	665	20.2	0.83	0.96
3–<10th percentile	223	11.6	396	12.0
≥10th percentile	1316	68.6	2233	67.8
IVH (grade III or IV) – PVL	132	7.0	207	6.4	0.38	0.32
Severe NEC (requiring surgery or peritoneal drainage)	39	2.0	63	1.9	0.77	0.59
ROP (grade III, IV or V)	65	3.4	154	4.7	0.03	0.13
Bronchopulmonary dysplasia‡	254	13.5	433	13.3	0.86	0.06
Any severe morbidity	212	11.3	366	11.3	0.99	0.79

PPROM: prolonged preterm rupture of membranes; HELLP, HELLP syndrome; SGA, small for gestational age; IVH, intraventricular haemorrhage; PVL, periventricular leukomalacia; NEC, necrotising enterocolitis; ROP, retinopathy of prematurity.
*Adjusted on region of birth.
†Without UK.
‡BPD – oxygen or respiratory support at 36 weeks’ GA.
EPICE, Effective Perinatal Intensive Care in Europe; GA, gestational age.