Table 3

Major adverse events and postnatal complications

Therapeutic hypothermia
(n=25)
Standard care
(n=25)
P value
Major adverse events
 Death or withdrawal of care during intervention2 (8)1 (4)0.55
 Major cardiac arrhythmia00
 Persistent hypotension00
 Prolonged coagulation time23 (92)19 (76)0.12
 Thrombocytopenia4 (16)2 (8)0.38
 Severe haemorrhage02 (8)*0.15
 PPHN00
 Culture-positive sepsis00
Postnatal complications
 Death or withdrawal of care after intervention04 (17)†0.04
 Clinical seizures20 (80)22 (88)0.44
 ≥2 anticonvulsants9 (36)12 (48)0.39
 Mechanical ventilation >24 hours2 (8)6 (24)0.12
 Inotropic support14 (56)17 (68)0.38
 Treated coagulopathy10 (40)8 (32)0.56
 Hypoglycaemia2 (8)1 (4)0.55
 Hyperglycaemia requiring insulin1 (4)1 (4)
  • Data are n (%).

  • *Both were subgaleal bleed requiring packed cell transfusion.

  • †Denominator 24 due to one withdrawal of care during the intervention.

  • PPHN, persistent pulmonary hypertension of the newborn.