Table 2

Outcome parameters of control group and intervention group in both NICUs

OutcomeControl group
(280 infants: NICU1+NICU2)
NIB intervention group
(281 infants: NICU1+NICU2)
aORs and
95% CI
Primary composite outcome:
new or progressive GMH-IVH within first 72 hours, in-hospital death or c-PVL, number of patients (%)
86 (31%) 49 (17%) aOR 0.42;
95% CI 0.27 to 0.65,
p<0.001
45 NICU118 NICU1
41 NICU231 NICU2
New or progressive GMH-IVH within first 72 hours after birth, number of patients (%) 65 (23%) 27 (10%) aOR 0.34;
95% CI 0.20 to 0.56,
p<0.001
33 NICU17 NICU1
32 NICU220 NICU2
c-PVL, number of patients (%) 3 (1%) 2 (1%) aOR 0.71;
95% CI 0.11 to 4.43,
p=0.71
2 NICU11 NICU1
1 NICU21 NICU2
In-hospital death, number of patients (%)28 (10%)29 (10%)aOR 1.04;
95% CI 0.55 to 1.95,
p=0.90
14 NICU113 NICU1
14 NICU216 NICU2
Composite outcome:
new or progressive severe* GMH-IVH within first 72 hours, in-hospital death or c-PVL, number of patients (%)
55 (20%)37 (13%)aOR 0.54,
95% CI 0.33 to 0.91,
p=0.02
30 NICU116 NICU1
25 NICU221 NICU2
Control group
survivors
(252 infants: NICU1+NICU2)
NIB intervention group
survivors
(252 infants: NICU1+NICU2)
New or progressive severe* GMH-IVH within first 72 hours after birth, number of patients (%)26 (9%)6 (2%)aOR 0.20,
95% CI 0.08 to 0.51,
p<0.001
15 NICU12 NICU1
11 NICU24 NICU2
  • *Severe GMH-IVH defined as a grade III haemorrhage, haemorrhages accompanied by periventricular haemorrhagic infarction and/or resulting in ventricular dilatation with need of intervention; Apgar score at 5 min, centre and CRIB score.

  • aOR, adjusted OR; c-PVL, cystic periventricular leukomalacia; GMH-IVH, germinal matrix-intraventricular haemorrhage; NIB, nursing intervention bundle; NICU, neonatal intensive care unit.