Table 2

Comparison of glucose control, insulin delivery and nutritional intake during the intervention period (48–72 hours postbirth)

Closed loop
(n=10)		Control
(n=10)		P value
Time spent with sensor glucose level (%)
4.0–8.0 mmol/L* 91 (78-99)26 (6-64)<0.001
2.6–10 mmol/L100 (94-100)84 (46-98)0.133
>10.0 mmol/L0 (0-6)16 (2-54)0.113
<2.6 mmol/L0.0 (0.0-0.0)0.0 (0.0-0.0)0.720
Baseline sensor glucose (mmol/L)7.9 (6.9-11.5)8.2 (7.0-12.4)0.182
Mean sensor glucose (mmol/L)6.2 (6.1-7.1)8.6 (7.4-11.1)0.002
SD of sensor glucose (mmol/L)1.0 (0.8-1.9)1.3 (0.9-2.5)0.604
Episodes of blood glucose <2.6 mmol/L† 101.000
Insulin (U/kg/hour)0.04 (0.03-0.07)0.02 (0.00-0.11)0.400
Nutritional intake
Dextrose (mg/kg/min)8.4 (7.2-10.3)8.5 (4.2-10.6)0.604
Protein (g/kg/day)3.2 (2.5-4.1)3.5 (1.6-4.1)1.000
Lipid (g/kg/day)1.8 (1.0-1.8)1.4 (0.9-2.2)0.905
Trophic feeds441.000

  • Data are presented as median (IQR).

  • ↵*Primary end point.

  • ↵†Present at start of closed-loop study period prior to computer algorithm advice being initiated.